Ekkehard Dikomey Selected Research

1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)

1/2022	IL1 Pathway in HPV-Negative HNSCC Cells Is an Indicator of Radioresistance After Photon and Carbon Ion Irradiation Without Functional Involvement.
2/2020	Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining.
11/2016	Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.
1/2016	Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.
11/2013	Sorafenib sensitizes head and neck squamous cell carcinoma cells to ionizing radiation.
5/2013	HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity.
1/2013	Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.
10/2011	In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.
3/2009	Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta.

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Ekkehard Dikomey Research Topics

Disease

20	Neoplasms (Cancer) 01/2022 - 07/2006
13	Squamous Cell Carcinoma of Head and Neck 06/2022 - 03/2013
4	Head and Neck Neoplasms (Head and Neck Cancer) 06/2022 - 08/2002
4	Fibrosis (Cirrhosis) 01/2015 - 08/2002
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2019 - 01/2013
3	Prostatic Neoplasms (Prostate Cancer) 01/2018 - 11/2016
3	Breast Neoplasms (Breast Cancer) 04/2012 - 11/2003
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/2018 - 10/2011
2	Glioblastoma (Glioblastoma Multiforme) 09/2016 - 10/2015
2	Erythema 01/2015 - 04/2012
2	Genomic Instability 05/2013 - 03/2012
2	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2012 - 08/2002
2	Chromosome Aberrations (Chromosome Abnormalities) 03/2009 - 08/2002
1	Aneuploidy (Aneuploid) 11/2019
1	Infections 06/2018
1	Ovarian Neoplasms (Ovarian Cancer) 11/2016
1	Neoplasm Metastasis (Metastasis) 01/2016
1	Adenocarcinoma 05/2013
1	Hypersensitivity (Allergy) 01/2013
1	Blast Crisis (Blast Phase) 01/2011
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2011
1	Disease Progression 01/2011
1	Telangiectasis (Telangiectasia) 08/2002
1	Xerostomia 08/2002
1	Nijmegen Breakage Syndrome 08/2002
1	Mucositis 08/2002

Drug/Important Bio-Agent (IBA)

9	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2022 - 03/2009
7	ErbB Receptors (EGF Receptor)IBA 10/2015 - 07/2006
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 10/2011
4	Proteins (Proteins, Gene)FDA Link 09/2015 - 07/2011
3	Sorafenib (BAY 43-9006)FDA Link 09/2016 - 11/2013
2	Cisplatin (Platino)FDA LinkGeneric 06/2022 - 04/2016
2	dactolisibIBA 06/2022 - 02/2020
2	CarbonIBA 01/2022 - 10/2020
2	Biological ProductsIBA 03/2019 - 12/2014
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2018 - 11/2016
2	Cetuximab (Erbitux)FDA Link 12/2014 - 03/2013
2	Codon (Codons)IBA 04/2012 - 10/2010
2	Carisoprodol (Soma)FDA LinkGeneric 10/2010 - 11/2003
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Proteasome InhibitorsIBA 03/2019
1	Bortezomib (Velcade)FDA Link 03/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2019
1	LipopolysaccharidesIBA 06/2018
1	CREB-Binding ProteinIBA 06/2018
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 12/2017
1	RoscovitineIBA 12/2017
1	Biomarkers (Surrogate Marker)IBA 02/2017
1	DNA HelicasesIBA 11/2016
1	epidermal growth factor receptor VIIIIBA 10/2015
1	Gefitinib (Iressa)FDA Link 10/2015
1	Amino Acids FDA Link 09/2015
1	IsotopesIBA 09/2015
1	olaparibIBA 12/2014
1	Cyclin-Dependent Kinase Inhibitor p16IBA 05/2013
1	Calcibiotic Root Canal SealerIBA 05/2013
1	MicroRNAs (MicroRNA)IBA 01/2013
1	Phosphotransferases (Kinase)IBA 09/2012
1	EndonucleasesIBA 09/2012
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2011
1	BIBR 1532IBA 01/2011
1	ORALIT (ORS)IBA 10/2010
1	Phosphatidylinositols (Phosphatidylinositol)IBA 07/2006
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2006
1	DNA Ligase ATPIBA 08/2002

Therapy/Procedure

13	Radiotherapy 02/2020 - 08/2002
11	Therapeutics 06/2018 - 08/2002
3	Chemoradiotherapy 06/2022 - 09/2013
1	Prostatectomy (Retropubic Prostatectomy) 01/2018
1	Segmental Mastectomy (Lumpectomy) 01/2015
1	Drug Therapy (Chemotherapy) 12/2014
1	Radioimmunotherapy 03/2013